Aldactone Drug Interactions: 137 Major, 162 Moderate
Aldactone (Spironolactone) Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Aldactone. Always confirm against the full prescribing information.
100 interactions
Acetylsalicylic acid
The therapeutic efficacy of Spironolactone can be decreased when used in combination with Acetylsalicylic acid.
Level 1 evidence
Albuterol
The therapeutic efficacy of Salbutamol can be decreased when used in combination with Spironolactone.
Level 2 evidence
Alfentanil
The risk or severity of orthostatic hypotension can be increased when Alfentanil is combined with Spironolactone.
Level 1 evidence
Amobarbital
The risk or severity of orthostatic hypotension can be increased when Amobarbital is combined with Spironolactone.
Level 1 evidence
Arformoterol
The therapeutic efficacy of Arformoterol can be decreased when used in combination with Spironolactone.
Level 2 evidence
Aripiprazole
The risk or severity of hypotension can be increased when Aripiprazole is combined with Spironolactone.
Level 1 evidence
Aripiprazole lauroxil
The risk or severity of hypotension can be increased when Aripiprazole lauroxil is combined with Spironolactone.
Level 1 evidence
Baclofen
The risk or severity of adverse effects can be increased when Baclofen is combined with Spironolactone.
Level 1 evidence
Bendroflumethiazide
The therapeutic efficacy of Spironolactone can be increased when used in combination with Bendroflumethiazide.
Level 1 evidence
Benzhydrocodone
The therapeutic efficacy of Spironolactone can be decreased when used in combination with Benzhydrocodone.
Level 2 evidence
Benzphetamine
The therapeutic efficacy of Benzphetamine can be decreased when used in combination with Spironolactone.
Level 2 evidence
Bisacodyl
The risk or severity of dehydration can be increased when Spironolactone is combined with Bisacodyl.
Level 2 evidence
Enter your NPI to unlock 15 major interactions for Aldactone
Aldactone (Spironolactone) has 997 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Aldactone (Spironolactone) has 137 major, 162 moderate, and 698 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Aldactone. Always confirm against the full prescribing information.