Pyrimethamine Drug Interactions: 26 Major, 39 Moderate
Pyrimethamine Drug Interactions
Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Pyrimethamine. Always confirm against the full prescribing information.
100 interactions
5-methyltetrahydrofolic acid
The therapeutic efficacy of Pyrimethamine can be decreased when used in combination with 5-methyltetrahydrofolic acid.
Level 2 evidence
Acetazolamide
The therapeutic efficacy of Pyrimethamine can be increased when used in combination with Acetazolamide.
Level 1 evidence
Acyclovir
The excretion of Acyclovir can be decreased when combined with Pyrimethamine.
Level 2 evidence
Articaine
The risk or severity of methemoglobinemia can be increased when Pyrimethamine is combined with Articaine.
Level 1 evidence
Baricitinib
The excretion of Baricitinib can be decreased when combined with Pyrimethamine.
Level 2 evidence
Benzocaine
The risk or severity of methemoglobinemia can be increased when Pyrimethamine is combined with Benzocaine.
Level 1 evidence
Benzyl alcohol
The risk or severity of methemoglobinemia can be increased when Pyrimethamine is combined with Benzyl alcohol.
Level 1 evidence
Bupivacaine
The risk or severity of methemoglobinemia can be increased when Pyrimethamine is combined with Bupivacaine.
Level 1 evidence
Butamben
The risk or severity of methemoglobinemia can be increased when Pyrimethamine is combined with Butamben.
Level 1 evidence
Capsaicin
The risk or severity of methemoglobinemia can be increased when Pyrimethamine is combined with Capsaicin.
Level 1 evidence
Abacavir
Abacavir may increase the hepatotoxic activities of Pyrimethamine.
Level 2 evidence
Abatacept
Pyrimethamine may increase the hepatotoxic activities of Abatacept.
Level 2 evidence
Enter your NPI to unlock 4 major interactions for Pyrimethamine
Pyrimethamine has 572 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Pyrimethamine has 26 major, 39 moderate, and 507 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Pyrimethamine. Always confirm against the full prescribing information.