Check all documented drug-to-drug interactions. Major, moderate, and minor interactions with descriptions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Symproic. Always confirm against the full prescribing information.
100 interactions
Alfentanil
The therapeutic efficacy of Alfentanil can be decreased when used in combination with Naldemedine.
Level 2 evidence
Amikacin
Naldemedine may decrease the excretion rate of Amikacin which could result in a higher serum level.
Level 2 evidence
Benzhydrocodone
The therapeutic efficacy of Benzhydrocodone can be decreased when used in combination with Naldemedine.
Level 2 evidence
Buprenorphine
The therapeutic efficacy of Buprenorphine can be decreased when used in combination with Naldemedine.
Level 2 evidence
Butorphanol
The therapeutic efficacy of Butorphanol can be decreased when used in combination with Naldemedine.
Level 2 evidence
Capreomycin
Naldemedine may decrease the excretion rate of Capreomycin which could result in a higher serum level.
Level 2 evidence
Carbamazepine
Naldemedine may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Level 2 evidence
Abacavir
Abacavir may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Level 2 evidence
Aceclofenac
Aceclofenac may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Level 2 evidence
Acetaminophen
Acetaminophen may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Level 2 evidence
Acetazolamide
Acetazolamide may increase the excretion rate of Naldemedine which could result in a lower serum level and potentially a reduction in efficacy.
Level 2 evidence
Acetylsalicylic acid
Acetylsalicylic acid may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Symproic (Naldemedine) has 524 documented drug interactions. Always review the full list with a pharmacist before co-prescribing.
Symproic (Naldemedine) has 4 major, 44 moderate, and 476 minor documented interactions.
A therapy excluded from this list does not necessarily mean no interaction exists between that therapy and Symproic. Always confirm against the full prescribing information.